Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
نویسندگان
چکیده
منابع مشابه
A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential.
Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral activities of antiretroviral drugs against SIV. Our results emphasize the importance of the dose-res...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2008
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm1777